The storyline begins with the end of the Sars epidemic in Hong Kong and the accidental death of Lawrence Ng's (Paul) ex-girlfriend Yoyo Mung (Tracy). Lawrence begins a tailspin, but fortunately Gigi Lai (Frances) is always there to support him. Bowie Lam (Henry) appears at the beginning of Healing Hands 3 with a new girlfriend, having broken up with Flora Chan (Annie) between Healing Hands 2 and 3. However, he soon breaks up and despite initial bad impressions of Melissa Ng (Sarah), the two become friends. The drama follows the challenges that the characters face- including the medical obstacles faced by the doctors of Yan Oi hospital and the love life troubles that the various couples of the series overcome.